Patient presents with complaints consistent with glioblastoma multiforme (GBM).  Symptoms include persistent headaches, new-onset seizures, cognitive decline, focal neurological deficits (e.g., hemiparesis, aphasia), and personality changes.  Magnetic resonance imaging (MRI) of the brain with contrast reveals a heterogeneously enhancing lesion with central necrosis,  surrounding edema, and evidence of infiltration into adjacent brain parenchyma.  The presumptive diagnosis of glioblastoma, WHO grade IV, is supported by the clinical presentation and radiographic findings.  Differential diagnoses include anaplastic astrocytoma, brain metastasis, and cerebral abscess.  A neurosurgical consultation has been obtained for tissue biopsy and potential resection.  Molecular testing, including IDH mutation status and MGMT promoter methylation analysis, will be performed on the obtained tissue sample to further characterize the tumor and guide treatment decisions.  Treatment plan includes discussion of maximal safe resection followed by concurrent chemoradiation with temozolomide, according to established guidelines.  Patient and family have been counseled regarding prognosis, treatment options, and potential side effects.  Referral to oncology, radiation oncology, and palliative care services will be made.  Follow-up MRI will be scheduled to assess treatment response.  ICD-10 code C71.9, Malignant neoplasm of brain, unspecified, is provisionally assigned pending histopathological confirmation.