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D72.1
ICD-10-CM
Hypereosinophilic Syndrome

Find comprehensive information on Hypereosinophilic Syndrome diagnosis, including clinical documentation, medical coding (ICD-10-CM D72.82), and healthcare management. Learn about symptoms, diagnostic criteria, treatment options, and the role of eosinophils in HES. This resource provides valuable insights for healthcare professionals, patients, and researchers seeking accurate information on hypereosinophilia and its associated conditions. Explore the latest research, best practices, and clinical guidelines for optimal patient care in Hypereosinophilic Syndrome.

Also known as

HES
Idiopathic Hypereosinophilic Syndrome
Lymphocytic Variant Hypereosinophilic Syndrome

Diagnosis Snapshot

Key Facts
  • Definition : Persistent high eosinophil count causing organ damage.
  • Clinical Signs : Fatigue, cough, shortness of breath, skin rashes, muscle aches, heart, lung, or nerve problems.
  • Common Settings : Hematology, Cardiology, Immunology, Allergy clinics, or specialized hospitals.

Related ICD-10 Code Ranges

Complete code families applicable to AAPC D72.1 Coding
D72.1

Hypereosinophilia

Elevated eosinophils in the blood.

D47.1

Eosinophilia

Increased eosinophils, unspecified cause.

D72.89

Other specified disorders involving eosinophils

Eosinophil-related disorders not elsewhere classified.

Code-Specific Guidance

Decision Tree for

Follow this step-by-step guide to choose the correct ICD-10 code.

Is the hypereosinophilia idiopathic/primary?

  • Yes

    Myeloid/Lymphoid neoplasm with eosinophilia?

  • No

    Is there a known secondary cause?

Code Comparison

Related Codes Comparison

When to use each related code

Description
Persistent eosinophilia >1500/mcL
Eosinophilic leukemia
Reactive eosinophilia

Documentation Best Practices

Documentation Checklist
  • Hypereosinophilia criteria documented (absolute eosinophil count >1500/µL for >6 months)
  • Organ damage due to eosinophilia documented or excluded
  • Secondary causes of eosinophilia ruled out (allergy, parasites, medications)
  • Molecular testing for FIP1L1-PDGFRA (if indicated)
  • ICD-10-CM code D72.1 documented

Coding and Audit Risks

Common Risks
  • Unspecified Eosinophilia

    Coding D72.1 (Eosinophilia) without specifying underlying cause or HES subtype risks underpayment and inaccurate data.

  • Missed Organ Damage

    Failing to code organ-specific manifestations of HES (e.g., cardiomyopathy) impacts severity and reimbursement.

  • Inconsistent Subtype Coding

    Variation in coding myeloproliferative HES vs. lymphocytic HES leads to data integrity and clinical trial recruitment issues.

Mitigation Tips

Best Practices
  • Document eosinophil counts, organ damage for ICD-10-CM D72.1 accurate coding.
  • Rule out secondary causes, document specific organ involvement for CDI.
  • Monitor drug therapies, document response for compliance and improved outcomes.
  • Regular follow-up, comprehensive documentation for HES variant identification, code specificity.
  • Genetic testing if indicated, document for targeted therapy, compliance with payer rules.

Clinical Decision Support

Checklist
  • 1. Persistent eosinophilia >1500/uL documented?
  • 2. Organ damage attributable to eosinophilia?
  • 3. Secondary causes of eosinophilia excluded (allergies, parasites, etc.)?
  • 4. Molecular testing for FIP1L1-PDGFRA considered?
  • 5. Referral to hematology/oncology specialist if suspected HES.

Reimbursement and Quality Metrics

Impact Summary
  • Hypereosinophilic Syndrome reimbursement hinges on accurate ICD-10-CM coding (D72.1) and supporting documentation for optimal payer reimbursements.
  • Quality metrics for HES focus on timely diagnosis, corticosteroid response, and monitoring for organ damage impacting hospital quality reporting.
  • Proper coding and documentation of HES complications (e.g., cardiac, pulmonary) influence case-mix index and resource allocation.
  • Timely initiation of treatment and monitoring, reflected in coding, impacts performance on quality measures related to HES management.

Streamline Your Medical Coding

Let S10.AI help you select the most accurate ICD-10 codes. Our AI-powered assistant ensures compliance and reduces coding errors.

Quick Tips

Practical Coding Tips
  • Document eosinophil counts
  • Specify organ involvement
  • Rule out secondary causes
  • Code underlying disease if known
  • Query physician for clarification

Documentation Templates

Hypereosinophilic Syndrome (HES) diagnosed.  Patient presents with [chief complaint e.g., persistent cough, fatigue, shortness of breath, skin rash, or other relevant symptom].  Physical examination reveals [document specific findings e.g., splenomegaly, cardiopulmonary abnormalities, skin lesions, or neurologic deficits].  Complete blood count (CBC) demonstrates marked eosinophilia with an absolute eosinophil count (AEC) persistently greater than 1500 cellsmcL confirmed on at least two separate occasions.  Bone marrow biopsy [performed or pending, results if available].  Serum tryptase level [measured or pending, results if available].  Cardiac evaluation including echocardiogram [performed, scheduled, or pending, results if available] to assess for endomyocardial fibrosis.  Pulmonary function tests [performed or pending, results if available].  Differential diagnosis includes secondary causes of eosinophilia such as parasitic infections, allergic reactions, drug reactions, and other hematologic malignancies.  These have been ruled out based on [explain basis for exclusion e.g., negative stool ova and parasites, negative allergen testing, review of medications, or other relevant tests].  Molecular testing for FIP1L1-PDGFRA fusion gene [performed or pending, results if available].  Given the persistent eosinophilia and clinical presentation, the diagnosis of Hypereosinophilic Syndrome is made.  Initiating treatment with [specify medication e.g., corticosteroids, tyrosine kinase inhibitors such as imatinib, or other relevant therapies].  Patient education provided on disease process, treatment plan, potential side effects of medications, and the importance of regular monitoring.  Follow-up scheduled in [ timeframe e.g., two weeks] to assess treatment response and adjust therapy as needed.  ICD-10 code D47.2, Hypereosinophilia, assigned.
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