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B27.90
ICD-10-CM
Infectious Mononucleosis

Find information on Infectious Mononucleosis diagnosis, including clinical documentation, medical coding, ICD-10 codes, and SNOMED CT codes. Learn about EBV serology, monospot test, lymphocytosis, and heterophile antibody testing for accurate Infectious Mononucleosis diagnosis and reporting. This resource provides healthcare professionals with essential information for proper documentation and coding of mononucleosis, ensuring accurate clinical records and efficient billing practices. Explore guidelines for diagnosing and managing Infectious Mononucleosis in a clinical setting.

Also known as

Mono
Glandular Fever
Kissing Disease

Diagnosis Snapshot

Key Facts
  • Definition : Viral infection (Epstein-Barr virus) causing fever, sore throat, and swollen lymph nodes.
  • Clinical Signs : Fatigue, fever, sore throat, swollen lymph glands, enlarged spleen, headache.
  • Common Settings : College campuses, high schools, healthcare settings, close-contact environments.

Related ICD-10 Code Ranges

Complete code families applicable to AAPC B27.90 Coding
B27

Infectious mononucleosis

Covers infectious mononucleosis caused by the Epstein-Barr virus.

B25-B34

Other viral diseases

Includes other specified viral diseases not classified elsewhere.

R50-R69

General symptoms and signs

Includes general symptoms like fever or fatigue, common in mononucleosis.

Code-Specific Guidance

Decision Tree for

Follow this step-by-step guide to choose the correct ICD-10 code.

Is the Infectious Mononucleosis caused by Epstein-Barr virus (EBV)?

  • Yes

    Any complications?

  • No

    Is the causative agent Cytomegalovirus (CMV)?

Code Comparison

Related Codes Comparison

When to use each related code

Description
Infectious Mononucleosis
Strep Throat
Cytomegalovirus (CMV)

Documentation Best Practices

Documentation Checklist
  • Document positive Monospot or heterophile antibody test.
  • Record symptoms: fatigue, fever, sore throat, lymphadenopathy.
  • Specify atypical lymphocytes on peripheral blood smear.
  • Include duration and severity of symptoms for accurate coding.
  • Note any complications like splenomegaly or hepatitis.

Coding and Audit Risks

Common Risks
  • Unspecified EBV Status

    Coding mononucleosis without specifying Epstein-Barr Virus (EBV) status can lead to inaccurate reporting and affect quality metrics. CDI should query for EBV confirmation.

  • Symptom Coding Errors

    Incorrectly coding symptoms instead of the confirmed mononucleosis diagnosis can lead to underreporting and missed revenue opportunities. Focus on ICD-10-CM B27 specificity.

  • Missing Complication Codes

    Failing to capture complication codes like splenomegaly or hepatitis related to infectious mononucleosis can impact reimbursement and severity scores. Thorough documentation is key.

Mitigation Tips

Best Practices
  • Document EBV serology for accurate IM diagnosis ICD-10 B27
  • Specify mononucleosis type (e.g., EBV) for CDI, SNOMED CT G05.81
  • For atypical IM, rule out other causes, improve HCC coding accuracy
  • Complete blood count CBC with differential aids IM diagnosis, ICD-10 R70.0
  • Distinguish IM from strep throat clinically, optimize antibiotic stewardship

Clinical Decision Support

Checklist
  • 1. Verify triad: fatigue, fever, pharyngitis. ICD-10: B27.9, Doc: Symptom onset
  • 2. Posterior cervical lymphadenopathy. ICD-10: R59.1, Doc: Physical exam
  • 3. Positive heterophile antibody test or EBV serology. Doc: Lab results
  • 4. Consider atypical lymphocytes on CBC. ICD-10: R79.89 Doc: Bloodwork

Reimbursement and Quality Metrics

Impact Summary
  • Infectious Mononucleosis reimbursement hinges on accurate EBV testing (ICD-10 B27) coding and documentation for optimal payer contracts.
  • Missed Mononucleosis diagnosis impacts quality metrics like infection control reporting and patient length of stay (ALOS).
  • Proper Mononucleosis coding (ICD-10 B27, relevant procedure codes) maximizes case mix index (CMI) accuracy for hospital reimbursement.
  • Timely Mononucleosis diagnosis linked to reduced complications, impacting quality scores related to readmissions and patient satisfaction.

Streamline Your Medical Coding

Let S10.AI help you select the most accurate ICD-10 codes for . Our AI-powered assistant ensures compliance and reduces coding errors.

Frequently Asked Questions

Common Questions and Answers

Q: How can I differentiate between infectious mononucleosis and strep throat in a pediatric patient presenting with pharyngitis and lymphadenopathy?

A: Differentiating between infectious mononucleosis (IM) and strep throat in a pediatric patient with pharyngitis and lymphadenopathy can be challenging due to overlapping symptoms. While both present with sore throat and swollen lymph nodes, several key features can help distinguish them. In IM, the lymphadenopathy is typically more generalized, involving posterior cervical, axillary, and inguinal nodes. Furthermore, IM often presents with fatigue, splenomegaly, and hepatomegaly, which are less common in strep throat. Atypical lymphocytes on peripheral blood smear are a hallmark of IM. Consider performing a heterophile antibody test (Monospot) or EBV-specific serologies (IgM and IgG antibodies to viral capsid antigen (VCA) and Epstein-Barr nuclear antigen (EBNA)) for definitive diagnosis of IM. Rapid strep tests and throat cultures are crucial to rule out strep throat. Explore how combined clinical findings and targeted laboratory testing can improve diagnostic accuracy in these cases. Learn more about the specific sensitivities and specificities of different diagnostic tests for IM.

Q: What are the evidence-based recommendations for managing splenomegaly in patients diagnosed with infectious mononucleosis, specifically regarding return to contact sports?

A: Managing splenomegaly in patients diagnosed with infectious mononucleosis is crucial to prevent splenic rupture, a potentially life-threatening complication. Current evidence suggests restricting contact sports and strenuous activities for at least 3-4 weeks after symptom onset, or even longer if splenomegaly persists. Serial ultrasound examinations can be used to monitor splenic size and guide return-to-play decisions. However, there is no universally agreed-upon size threshold for safe return to contact sports. Consider implementing a gradual return-to-activity protocol based on individual patient assessment, including resolution of symptoms, splenic size, and overall clinical status. Learn more about the potential risks associated with premature return to contact sports in patients with IM and explore the latest guidelines for managing splenomegaly in this population.

Quick Tips

Practical Coding Tips
  • Code Epstein-Barr virus (EBV)
  • Document monospot or EBV serology
  • Specify symptoms like fatigue, fever, sore throat
  • Consider acute vs. chronic/convalescent
  • Check for splenomegaly or lymphadenopathy

Documentation Templates

Subjective: Patient presents with a chief complaint of fatigue, malaise, and sore throat.  Symptoms onset approximately one week ago and have progressively worsened.  Patient reports difficulty swallowing, headache, and low-grade fever.  Denies cough or runny nose.  Patient reports close contact with individuals diagnosed with mononucleosis. Review of systems reveals lymphadenopathy, pharyngitis, and splenomegaly on physical exam.

Objective:  Vital signs stable with a low-grade fever of 100.5 degrees Fahrenheit.  Physical examination reveals palpable cervical lymphadenopathy, tonsillar exudates, and mild splenomegaly.  Rapid strep test negative.  Complete blood count demonstrates lymphocytosis with atypical lymphocytes.  Monospot test positive, confirming the diagnosis of infectious mononucleosis.  Epstein-Barr virus serology pending.

Assessment:  Infectious mononucleosis (IM) secondary to Epstein-Barr virus (EBV) infection.  Patient meets diagnostic criteria for IM based on clinical presentation, positive Monospot test, and lymphocytosis with atypical lymphocytes.  Differential diagnoses considered included strep throat, cytomegalovirus infection, and toxoplasmosis.

Plan:  Supportive care recommended, including rest, hydration, and over-the-counter pain relievers for fever and sore throat management.  Patient educated on the importance of avoiding contact sports for at least four weeks due to risk of splenic rupture.  Follow-up scheduled in two weeks to assess symptom resolution and monitor for potential complications such as splenomegaly, hepatitis, or airway obstruction.  Patient advised to return sooner if symptoms worsen or new symptoms develop.  ICD-10 code B27 assigned.