Patient presents with suspected iodine allergy.  Symptoms reported include urticaria, pruritus, angioedema, skin rash, itching, swelling, respiratory distress, dyspnea, wheezing, nausea, vomiting, abdominal pain, diarrhea, hypotension, andor anaphylaxis following exposure to iodine-containing substances.  Potential iodine exposure sources documented include contrast media for CT scan or angiogram, povidone-iodine antiseptic solution, certain medications, andor dietary intake of iodine-rich foods like seaweed.  Differential diagnosis considered iodine hypersensitivity, seafood allergy, and other allergic reactions.  Allergy testing including skin prick test andor serum specific IgE antibody test for iodine may be indicated.  Diagnosis of iodine allergy is based on clinical presentation, history of exposure, and positive allergy testing if performed.  Treatment plan includes avoidance of iodine-containing substances, premedication with antihistamines and corticosteroids prior to necessary iodine exposure if unavoidable, and emergency management of anaphylaxis with epinephrine injection if it occurs.  Patient education provided on iodine allergy management, avoidance strategies, and emergency preparedness.  ICD-10 code T78.40XA, adverse effect of unspecified drug, medicinal and biological substance, initial encounter, may be applicable depending on specific circumstances.  CPT codes for allergy testing and evaluation may also be applicable.  Follow-up recommended for ongoing monitoring and management of iodine allergy.