Patient presents with signs and symptoms suggestive of leukemia.  Presenting complaints include fatigue, weakness, pallor, unexplained bruising, petechiae, recurrent infections, bone pain, and unintentional weight loss.  Physical examination may reveal hepatosplenomegaly, lymphadenopathy, or sternal tenderness.  Complete blood count (CBC) demonstrates abnormalities such as anemia, thrombocytopenia, leukocytosis, or the presence of blasts.  Peripheral blood smear review is crucial for morphological assessment of abnormal cells.  Bone marrow biopsy and aspiration are indicated for definitive diagnosis and classification of leukemia, including immunophenotyping, cytogenetic analysis, and molecular studies.  Differential diagnosis includes other hematological malignancies such as lymphoma, myelodysplastic syndrome, and aplastic anemia.  Based on the results of these diagnostic tests, the patient's leukemia is classified as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), or chronic lymphocytic leukemia (CLL).  The specific subtype and risk stratification will guide treatment decisions.  Treatment options for leukemia include chemotherapy, targeted therapy, immunotherapy, stem cell transplantation, and supportive care.  The patient's prognosis depends on factors such as age, leukemia subtype, cytogenetic abnormalities, and response to treatment.  Follow-up care includes monitoring of blood counts, disease status, and management of treatment-related side effects.  Medical coding and billing for leukemia involves ICD-10 codes (C91-C95) and appropriate CPT codes for procedures performed, such as bone marrow biopsy and aspiration.  This documentation is intended for healthcare professionals and should be used in conjunction with clinical judgment and established guidelines for leukemia diagnosis and management.