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C45.9
ICD-10-CM
Mesothelioma

Find information on mesothelioma diagnosis, including ICD-10 codes (C45.0-C45.9), clinical documentation requirements, malignant mesothelioma staging, pleural mesothelioma symptoms, peritoneal mesothelioma treatment, and asbestos exposure link. Learn about pathology reports, diagnostic criteria, and best practices for healthcare professionals involved in mesothelioma patient care. This resource provides guidance on medical coding and billing for mesothelioma-related services.

Also known as

Malignant Mesothelioma
Asbestos Cancer

Diagnosis Snapshot

Key Facts
  • Definition : Rare cancer linked to asbestos exposure, affecting the lining of lungs, abdomen, or heart.
  • Clinical Signs : Shortness of breath, chest pain, persistent cough, abdominal pain, fluid buildup.
  • Common Settings : Oncology clinics, thoracic surgery departments, hospitals with asbestos exposure treatment programs.

Related ICD-10 Code Ranges

Complete code families applicable to AAPC C45.9 Coding
C45.0-C45.9

Mesothelioma

Malignant neoplasm of the pleura, peritoneum, pericardium, and other sites.

C38.4

Malignant neoplasm of the trachea

Can include mesothelioma if it originates in the trachea.

C77.0-C77.9

Secondary malignant neoplasm of respiratory and intrathoracic organs

Includes mesothelioma that has spread to these locations from elsewhere.

D48.1

Neoplasm of uncertain behavior of pleura

Relevant for cases where the mesothelial tumor's nature is not yet fully determined.

Code-Specific Guidance

Decision Tree for

Follow this step-by-step guide to choose the correct ICD-10 code.

Is the mesothelioma malignant?

  • Yes

    Pleural mesothelioma?

  • No

    Is the mesothelioma benign?

Code Comparison

Related Codes Comparison

When to use each related code

Description
Malignant mesothelial tumor
Pleural effusion
Asbestosis

Documentation Best Practices

Documentation Checklist
  • Mesothelioma diagnosis documentation checklist
  • ICD-10 C45 Malignant mesothelioma coding
  • Laterality (right/left)
  • Histological subtype confirmation
  • Primary site specification
  • Asbestos exposure documentation

Coding and Audit Risks

Common Risks
  • Histology Miscoding

    Incorrect coding of mesothelioma histology (epithelioid, sarcomatoid, biphasic) impacts staging and treatment, leading to inaccurate reimbursement.

  • Laterality and Site Specificity

    Missing or incorrect laterality (right/left) and specific site (pleura, peritoneum, etc.) can affect treatment planning and data analysis.

  • Asbestos Exposure Documentation

    Insufficient documentation linking mesothelioma to asbestos exposure may hinder accurate coding and medico-legal implications.

Mitigation Tips

Best Practices
  • Accurate ICD-10 coding (C38.-, C45.-) for mesothelioma type/site
  • Thorough clinical documentation of asbestos exposure history is crucial
  • Timely pathology reports with detailed immunohistochemistry for accurate diagnosis
  • Regular CDI reviews for mesothelioma cases ensure compliant billing
  • Multidisciplinary team approach optimizes mesothelioma patient management

Clinical Decision Support

Checklist
  • 1. Verify pleural effusion or thickening: ICD-10 C38.4, imaging confirmation
  • 2. Histopathology: Malignant mesothelial cells, ICD-O-3 C45.0-C45.9
  • 3. Exposure history: Asbestos, erionite, radiation documented
  • 4. R/O other cancers: Lung, breast, clinical documentation complete
  • 5. Staging: TNM system, record extent/spread for treatment plan

Reimbursement and Quality Metrics

Impact Summary
  • Mesothelioma reimbursement hinges on accurate ICD-10-CM (C45.-) coding, impacting hospital case mix index.
  • Precise coding of procedures (thoracoscopy, pleurectomy) maximizes mesothelioma reimbursement.
  • Timely, complete documentation improves mesothelioma billing and reduces claim denials.
  • Mesothelioma quality reporting impacts hospital value-based purchasing programs and public rankings.

Streamline Your Medical Coding

Let S10.AI help you select the most accurate ICD-10 codes for . Our AI-powered assistant ensures compliance and reduces coding errors.

Quick Tips

Practical Coding Tips
  • Code C45.0-C45.9 for mesothelioma
  • Specify histology/site for accuracy
  • Document exposure history (asbestos)
  • Use laterality codes when applicable
  • Check ICD-10-CM guidelines yearly

Documentation Templates

Patient presents with complaints consistent with possible malignant mesothelioma.  Symptoms include progressively worsening dyspnea, persistent cough, and chest pain, potentially indicative of pleural mesothelioma.  The patient also reports fatigue, weight loss, and night sweats.  Physical examination revealed decreased breath sounds and dullness to percussion.  Occupational history includes extensive asbestos exposure during employment as a shipyard worker from 1970 to 1995, a significant risk factor for asbestos-related mesothelioma.  Differential diagnosis includes lung cancer, pleural effusion of other etiologies, and sarcomatoid mesothelioma.  Imaging studies, including chest x-ray and CT scan of the chest, abdomen, and pelvis, were ordered to assess the extent of pleural thickening and potential metastasis.  Thoracoscopy with pleural biopsy is scheduled to obtain tissue for histopathological confirmation of mesothelioma diagnosis and subtype determination (epithelioid, sarcomatoid, or biphasic).  Pulmonary function tests will be conducted to evaluate respiratory compromise.  Based on the clinical presentation, occupational history, and preliminary imaging findings, mesothelioma is a high clinical suspicion.  Further diagnostic evaluation and staging are necessary to determine the best course of treatment, which may include surgery (pleurectomydecortication, extrapleural pneumonectomy), chemotherapy (pemetrexed, cisplatin), radiation therapy, or a combination of these modalities.  Patient education regarding mesothelioma prognosis, treatment options, palliative care, and clinical trials was initiated.  Referral to oncology and pulmonology specialists has been made.  Follow-up appointment scheduled to discuss biopsy results and formulate a comprehensive treatment plan.  ICD-10 code C45.0 will be used pending biopsy confirmation.  Medical billing codes will be determined based on the specific procedures performed and treatment modalities utilized.
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