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D47.2
ICD-10-CM
Monoclonal Paraproteinemia

Find clear information on Monoclonal Gammopathy of Undetermined Significance MGUS and Smoldering Multiple Myeloma SMM related to Monoclonal Paraproteinemia. Learn about diagnosis codes, ICD-10 codes like D47.2, laboratory findings including serum protein electrophoresis SPEP and urine protein electrophoresis UPEP, M protein, and free light chain assay. This resource offers guidance on clinical documentation improvement CDI, healthcare terminology, and medical coding best practices for Monoclonal Paraproteinemia, plasma cell dyscrasias, and related conditions.

Also known as

Monoclonal Gammopathy
MGUS
Monoclonal Gammopathy of Undetermined Significance

Diagnosis Snapshot

Key Facts
  • Definition : Overproduction of a single type of antibody by plasma cells.
  • Clinical Signs : Often asymptomatic. Fatigue, bone pain, infections, kidney problems, and neuropathy can occur.
  • Common Settings : Detected through routine blood tests or during investigation of related symptoms.

Related ICD-10 Code Ranges

Complete code families applicable to AAPC D47.2 Coding
D47.2

Monoclonal gammopathy

Presence of a monoclonal paraprotein in the blood.

C90.0-C90.2

Multiple myeloma

Malignant proliferation of plasma cells producing a monoclonal paraprotein.

C88.0-C88.9

Waldenstrom macroglobulinemia

Lymphoplasmacytic lymphoma with IgM monoclonal paraprotein.

D89.2

Cryoglobulinemia

Presence of abnormal immunoglobulins that precipitate at low temperatures, sometimes monoclonal.

Code-Specific Guidance

Decision Tree for

Follow this step-by-step guide to choose the correct ICD-10 code.

Is the monoclonal paraproteinemia associated with a known plasma cell disorder?

  • Yes

    Is it Multiple Myeloma?

  • No

    Is it MGUS?

Code Comparison

Related Codes Comparison

When to use each related code

Description
Monoclonal gammopathy
Smoldering myeloma
Multiple myeloma

Documentation Best Practices

Documentation Checklist
  • Serum protein electrophoresis (SPEP) results
  • Immunofixation electrophoresis findings
  • Quantify M-protein: type, size
  • Bone marrow biopsy results (if done)
  • Clinical symptoms related to paraprotein

Mitigation Tips

Best Practices
  • Document M protein type, quantity for accurate ICD-10 coding (C90.0-C90.2).
  • Ensure complete SPEP, UPEP, immunofixation results in chart for CDI.
  • Query physician for clarity on MGUS vs. MM for correct coding, compliant billing.
  • Regularly review, update monoclonal gammopathy documentation per NCCN guidelines.
  • Code precisely for bone marrow biopsy, aspirate if performed (38220, 38221).

Clinical Decision Support

Checklist
  • Serum protein electrophoresis (SPEP) ordered?
  • Immunofixation or free light chain assay?
  • Bone marrow biopsy considered/performed?
  • Clinical symptoms documented (e.g., anemia, bone pain)?
  • MGUS vs. MM workup initiated/documented?

Reimbursement and Quality Metrics

Impact Summary
  • Monoclonal Paraproteinemia reimbursement hinges on accurate ICD-10 coding (D47.2-) and reporting for optimal payer coverage.
  • Coding specificity impacts MS-DRG assignment and case-mix index affecting hospital reimbursement for MGUS cases.
  • Timely and complete documentation of M protein type and quantity influences lab test billing and medical necessity reviews.
  • Accurate paraprotein reporting improves quality metrics for multiple myeloma-related complications monitoring and care.

Streamline Your Medical Coding

Let S10.AI help you select the most accurate ICD-10 codes for . Our AI-powered assistant ensures compliance and reduces coding errors.

Quick Tips

Practical Coding Tips
  • Code underlying plasma cell disorder
  • Document M-protein type/level
  • Specify organ/system involvement
  • Query physician for clarity
  • Consider MGUS if asymptomatic

Documentation Templates

Patient presents with signs and symptoms suggestive of monoclonal gammopathy of undetermined significance (MGUS) or monoclonal paraproteinemia, possibly progressing towards multiple myeloma.  Presenting complaints include fatigue, bone pain specifically in the back or ribs, recurrent infections, and unexplained weight loss.  Laboratory findings reveal an M-spike on serum protein electrophoresis (SPEP) and immunofixation (IFE) confirming the presence of a monoclonal protein.  Quantitative immunoglobulin levels (IgG, IgA, IgM) have been measured.  A bone marrow biopsy has been ordered to assess plasma cell percentage and rule out smoldering multiple myeloma or active multiple myeloma.  Skeletal survey or low-dose CT scan is planned to evaluate for lytic lesions.  Urinalysis including Bence Jones protein is pending.  Differential diagnosis includes other plasma cell dyscrasias, Waldenstrom's macroglobulinemia, and amyloidosis.  Current plan is to monitor patient closely with serial SPEP, IFE, and free light chain assays.  Patient education provided regarding the nature of monoclonal gammopathy, potential complications, and the need for ongoing surveillance.  Referral to hematologyoncology is made for further evaluation and management.  ICD-10 code M80.00 (Monoclonal gammopathy of undetermined significance) is tentatively assigned, pending further diagnostic workup.  Medical billing codes will be finalized upon completion of the diagnostic evaluation and establishment of a definitive diagnosis.