Patient presents with signs and symptoms suggestive of Mycobacterium avium complex MAC infection, likely due to Mycobacterium avium intracellulare MAI.  Clinical manifestations include persistent cough, productive or nonproductive, fatigue, weight loss, fever, night sweats, and occasionally, lymphadenopathy.  Pulmonary MAC disease is suspected, given the patient's respiratory symptoms and history of  underlying lung conditions such as chronic obstructive pulmonary disease COPD or prior bronchiectasis.  Disseminated MAC infection is considered given the systemic symptoms of fever, night sweats, and weight loss.  Differential diagnoses include tuberculosis, fungal pneumonia, and other opportunistic infections.  Diagnostic workup includes sputum culture for acid-fast bacilli AFB smear and culture, chest x-ray, and high-resolution computed tomography HRCT of the chest.  Blood cultures may be indicated to assess for disseminated disease.  Treatment for MAC infection will be initiated pending culture confirmation and susceptibility testing, considering a macrolide antibiotic such as azithromycin or clarithromycin in combination with ethambutol.  Rifabutin may be added to the regimen depending on disease severity and drug susceptibility.  Patient education provided regarding medication adherence, potential side effects, and the importance of follow-up care for monitoring treatment response and potential adverse events.  ICD-10 code A31.0 disseminated MAI is provisionally assigned, with potential for refinement based on culture results and disease localization.  CPT codes for diagnostic testing and therapeutic procedures will be documented accordingly.  Further evaluation and management will be based on the evolving clinical picture and response to therapy.