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E22.1
ICD-10-CM
Prolactinemia

Understand prolactinemia diagnosis, including elevated prolactin levels, causes, symptoms, and treatment. Find information on hyperprolactinemia, prolactin blood test, pituitary adenoma, galactorrhea, amenorrhea, infertility, and medication side effects. Learn about ICD-10 code E22.1 for prolactinemia, medical coding guidelines, clinical documentation improvement, and healthcare resources for patients and professionals.

Also known as

Hyperprolactinemia
Elevated prolactin levels

Diagnosis Snapshot

Key Facts
  • Definition : High prolactin levels in the blood.
  • Clinical Signs : Irregular periods, milky nipple discharge, infertility, headaches.
  • Common Settings : Primary care, endocrinology, infertility clinics.

Related ICD-10 Code Ranges

Complete code families applicable to AAPC E22.1 Coding
E22.1

Hyperprolactinemia

Elevated prolactin levels in the blood.

E22.9

Pituitary disorder, unspecified

Unspecified disorder of the pituitary gland, which can cause prolactinemia.

N64.89

Other specified disorders of breast

Includes galactorrhea, sometimes caused by hyperprolactinemia.

R79.89

Other abnormal findings of blood chemistry

Can be used for abnormal prolactin levels if no other cause is found.

Code-Specific Guidance

Decision Tree for

Follow this step-by-step guide to choose the correct ICD-10 code.

Is the prolactinemia due to a drug or other external agent?

  • Yes

    Code D58.2 Drug-induced hyperprolactinemia

  • No

    Is the prolactinemia associated with pregnancy?

Code Comparison

Related Codes Comparison

When to use each related code

Description
High prolactin level
Drug-induced hyperprolactinemia
Prolactinoma

Documentation Best Practices

Documentation Checklist
  • Prolactinemia diagnosis: Document elevated prolactin level (ng/mL)
  • Specify prolactin assay method used
  • Document symptoms (galactorrhea, amenorrhea, infertility)
  • Exclude medications causing hyperprolactinemia
  • Rule out other causes like pituitary adenoma

Coding and Audit Risks

Common Risks
  • Unspecified Prolactinemia

    Coding E22.1 without identifying underlying cause (medication, pituitary adenoma) leads to inaccurate reporting and potential DRG misclassification.

  • Drug-Induced Coding

    Failing to code drug-induced hyperprolactinemia (E22.1, with appropriate external cause code) impacts pharmacovigilance and quality metrics.

  • Physiological Elevation

    Incorrectly coding normal physiological hyperprolactinemia (pregnancy, lactation) as pathological can trigger unnecessary investigations and treatment.

Mitigation Tips

Best Practices
  • Document medication history for accurate ICD-10-CM coding (E22.1).
  • Rule out drug-induced hyperprolactinemia for compliant E/M coding.
  • Order appropriate lab tests with precise LOINC codes for prolactin levels.
  • Specify prolactinoma type (microadenoma/macroadenoma) for proper CPT coding.
  • Correlate clinical findings with imaging (SNOMED CT) for CDI of prolactinemia.

Clinical Decision Support

Checklist
  • Verify elevated serum prolactin level (ICD-10 E22.1)
  • Rule out medications as cause (drug-induced hyperprolactinemia)
  • Assess for signs/symptoms: amenorrhea, galactorrhea
  • Consider pituitary MRI if indicated (imaging documentation)

Reimbursement and Quality Metrics

Impact Summary
  • Prolactinemia reimbursement hinges on accurate ICD-10-CM coding (E22.1) and appropriate CPT codes for lab tests (e.g., 84146). Proper documentation supports medical necessity for optimal payment.
  • Quality metrics impacted: Elevated prolactin levels may trigger Endocrinology referral (e.g., HEDIS measure), influencing hospital quality reporting and potential penalties.
  • Coding accuracy directly impacts case mix index (CMI) for Prolactinemia, affecting DRG assignment and hospital reimbursement. Correct coding ensures appropriate resource reflection.
  • Timely and specific diagnosis coding for Prolactinemia improves data analysis for resource allocation, treatment efficacy studies, and public health reporting.

Streamline Your Medical Coding

Let S10.AI help you select the most accurate ICD-10 codes for . Our AI-powered assistant ensures compliance and reduces coding errors.

Quick Tips

Practical Coding Tips
  • Code primary hyperprolactinemia E22.1
  • Medication-induced? Code E24.2
  • Document prolactin level units ng/mL
  • Rule out other causes in documentation
  • Check for pregnancy status if applicable

Documentation Templates

Patient presents with complaints suggestive of prolactinemia, including galactorrhea, amenorrhea, oligomenorrhea, infertility, decreased libido, andor erectile dysfunction.  Onset and duration of symptoms were documented.  Past medical history, surgical history, family history, and medication history, including the use of dopamine antagonists, antipsychotics, antidepressants, and antihypertensives, were reviewed for potential contributing factors.  Physical examination findings were noted, including the presence or absence of galactorrhea and assessment of visual fields.  Laboratory results confirmed elevated prolactin levels.  Differential diagnoses considered included pituitary adenoma, hypothyroidism, polycystic ovary syndrome, medications, and other causes of hyperprolactinemia.  A pregnancy test was performed if applicable.  Brain MRI with pituitary protocol was ordered or is planned to evaluate for pituitary adenoma or other structural abnormalities.  The patient was counseled on the potential causes of hyperprolactinemia, treatment options, and the importance of follow-up.  Initial management may include dopamine agonist therapy such as cabergoline or bromocriptine, with dosage and frequency documented.  Patient education regarding medication side effects, monitoring, and potential complications was provided.  Follow-up appointments were scheduled to monitor prolactin levels, assess treatment response, and adjust management as needed.  ICD-10 code E22.1 (Hyperprolactinemia) is documented for billing and coding purposes.  CPT codes for laboratory tests, imaging studies, and office visits are documented as appropriate.