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Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D55-D59

Hemolytic anemias

Explore comprehensive insights on hemolytic anemias (ICD-10 D55-D59) with a focus on clinical relevance, accurate documentation, and precise coding. Enhance your understanding of these conditions, including diagnosis, treatment, and management, to improve patient outcomes and streamline healthcare workflows.

About This Range
96+
Total codes
79+
Billable codes
17+
Non-billable codes
3
Chapters
Codes in this Range (96+)
Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Range: D50-D89
D55
Anemia due to enzyme disorders
D55.0
Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
Billable
D55.1
Anemia due to other disorders of glutathione metabolism
Billable
D55.2
Anemia due to disorders of glycolytic enzymes
D55.21
Anemia due to pyruvate kinase deficiency
Billable
D55.29
Anemia due to other disorders of glycolytic enzymes
Billable
D55.3
Anemia due to disorders of nucleotide metabolism
Billable
D55.8
Other anemias due to enzyme disorders
Billable
D55.9
Anemia due to enzyme disorder, unspecified
Billable
D56
Thalassemia
D56.0
Alpha thalassemia
Billable
D56.1
Beta thalassemia
Billable
D56.2
Delta-beta thalassemia
Billable
D56.3
Thalassemia minor
Billable
D56.4
Hereditary persistence of fetal hemoglobin [HPFH]
Billable
D56.5
Hemoglobin E-beta thalassemia
Billable
D56.8
Other thalassemias
Billable
D56.9
Thalassemia, unspecified
Billable
D57
Sickle-cell disorders
D57.0
Hb-SS disease with crisis
D57.00
Hb-SS disease with crisis, unspecified
Billable
D57.01
Hb-SS disease with acute chest syndrome
Billable
D57.02
Hb-SS disease with splenic sequestration
Billable
D57.03
Hb-SS disease with cerebral vascular involvement
Billable
D57.04
Hb-SS disease with dactylitis
Billable
D57.09
Hb-SS disease with crisis with other specified complication
Billable
D57.1
Sickle-cell disease without crisis
Billable
D57.2
Sickle-cell/Hb-C disease
D57.20
Sickle-cell/Hb-C disease without crisis
Billable
D57.21
Sickle-cell/Hb-C disease with crisis
D57.211
Sickle-cell/Hb-C disease with acute chest syndrome
Billable
D57.212
Sickle-cell/Hb-C disease with splenic sequestration
Billable
D57.213
Sickle-cell/Hb-C disease with cerebral vascular involvement
Billable
D57.214
Sickle-cell/Hb-C disease with dactylitis
Billable
D57.218
Sickle-cell/Hb-C disease with crisis with other specified complication
Billable
D57.219
Sickle-cell/Hb-C disease with crisis, unspecified
Billable
D57.3
Sickle-cell trait
Billable
D57.4
Sickle-cell thalassemia
D57.40
Sickle-cell thalassemia without crisis
Billable
D57.41
Sickle-cell thalassemia, unspecified, with crisis
D57.411
Sickle-cell thalassemia, unspecified, with acute chest syndrome
Billable
D57.412
Sickle-cell thalassemia, unspecified, with splenic sequestration
Billable
D57.413
Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
Billable
D57.414
Sickle-cell thalassemia, unspecified, with dactylitis
Billable
D57.418
Sickle-cell thalassemia, unspecified, with crisis with other specified complication
Billable
D57.419
Sickle-cell thalassemia, unspecified, with crisis
Billable
D57.42
Sickle-cell thalassemia beta zero without crisis
Billable
D57.43
Sickle-cell thalassemia beta zero with crisis
D57.431
Sickle-cell thalassemia beta zero with acute chest syndrome
Billable
D57.432
Sickle-cell thalassemia beta zero with splenic sequestration
Billable
D57.433
Sickle-cell thalassemia beta zero with cerebral vascular involvement
Billable
D57.434
Sickle-cell thalassemia beta zero with dactylitis
Billable
D57.438
Sickle-cell thalassemia beta zero with crisis with other specified complication
Billable
D57.439
Sickle-cell thalassemia beta zero with crisis, unspecified
Billable
D57.44
Sickle-cell thalassemia beta plus without crisis
Billable
D57.45
Sickle-cell thalassemia beta plus with crisis
D57.451
Sickle-cell thalassemia beta plus with acute chest syndrome
Billable
D57.452
Sickle-cell thalassemia beta plus with splenic sequestration
Billable
D57.453
Sickle-cell thalassemia beta plus with cerebral vascular involvement
Billable
D57.454
Sickle-cell thalassemia beta plus with dactylitis
Billable
D57.458
Sickle-cell thalassemia beta plus with crisis with other specified complication
Billable
D57.459
Sickle-cell thalassemia beta plus with crisis, unspecified
Billable
D57.8
Other sickle-cell disorders
D57.80
Other sickle-cell disorders without crisis
Billable
D57.81
Other sickle-cell disorders with crisis
D57.811
Other sickle-cell disorders with acute chest syndrome
Billable
D57.812
Other sickle-cell disorders with splenic sequestration
Billable
D57.813
Other sickle-cell disorders with cerebral vascular involvement
Billable
D57.814
Other sickle-cell disorders with dactylitis
Billable
D57.818
Other sickle-cell disorders with crisis with other specified complication
Billable
D57.819
Other sickle-cell disorders with crisis, unspecified
Billable
D58
Other hereditary hemolytic anemias
D58.0
Hereditary spherocytosis
Billable
D58.1
Hereditary elliptocytosis
Billable
D58.2
Other hemoglobinopathies
Billable
D58.8
Other specified hereditary hemolytic anemias
Billable
D58.9
Hereditary hemolytic anemia, unspecified
Billable
D59
Acquired hemolytic anemia
D59.0
Drug-induced autoimmune hemolytic anemia
Billable
D59.1
Other autoimmune hemolytic anemias
D59.10
Autoimmune hemolytic anemia, unspecified
Billable
D59.11
Warm autoimmune hemolytic anemia
Billable
D59.12
Cold autoimmune hemolytic anemia
Billable
D59.13
Mixed type autoimmune hemolytic anemia
Billable
D59.19
Other autoimmune hemolytic anemia
Billable
D59.2
Drug-induced nonautoimmune hemolytic anemia
Billable
D59.3
Hemolytic-uremic syndrome
D59.30
Hemolytic-uremic syndrome, unspecified
Billable
D59.31
Infection-associated hemolytic-uremic syndrome
Billable
D59.32
Hereditary hemolytic-uremic syndrome
Billable
D59.39
Other hemolytic-uremic syndrome
Billable
D59.4
Other nonautoimmune hemolytic anemias
Billable
D59.5
Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
Billable
D59.6
Hemoglobinuria due to hemolysis from other external causes
Billable
D59.8
Other acquired hemolytic anemias
Billable
D59.9
Acquired hemolytic anemia, unspecified
Billable

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Frequently Asked Questions
What are the common causes of hemolytic anemia?

Hemolytic anemia can be caused by various factors including autoimmune disorders, genetic conditions like sickle cell anemia and thalassemia, infections, certain medications, and exposure to toxic chemicals. Identifying the underlying cause is crucial for effective treatment.

How is hemolytic anemia diagnosed?

Hemolytic anemia is diagnosed through a combination of blood tests such as a complete blood count (CBC), reticulocyte count, and peripheral blood smear. Additional tests like direct antiglobulin test (DAT) and haptoglobin levels may be used to determine the specific type and cause of hemolysis.

What treatment options are available for hemolytic anemia?

Treatment for hemolytic anemia depends on the underlying cause. Options may include corticosteroids for autoimmune hemolytic anemia, blood transfusions for severe cases, or medications like hydroxyurea for sickle cell anemia. In some cases, splenectomy or immunosuppressive therapy may be recommended.

Hemolytic anemias